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Zin, Thant
- Accessibility and Availability, Sociodemographic Characteristics, Health Centre Facilities and Knowledge, Attitude and Practice towards Modifiable Lifestyle Diseases among Adult Population in East Coast Malaysia-A Cross-sectional Study
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Authors
U. S. Mahadeva Rao
1,
San San Oo
1,
Nurul Liana Sabrin
1,
Norsyahira Syazwana Mohd Razali
1,
Khairunnisa Khalid
1,
Nurul Farihah Mohamed Nadzari
1,
Thant Zin
1
Affiliations
1 Universiti Sultan Zainal Abidin, MY
1 Universiti Sultan Zainal Abidin, MY
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 317-324Abstract
Background: Modifiable Lifestyle Disease (MLD) can give rise to many complications. If left untreated, the disease can affect one's quality of life. MLD can be prevented by modifying our sedentary lifestyle and dietary practice. Introduction: Nowadays, people are aware of the effect of MLDs in their life but the treatment preferences are different among various people. Objective: This study was conducted to identify the treatment seeking behaviour (TSB) among adult populations in East coast Malaysia (Kampung Ladang Sehat, Kuala Terengganu). Method: The survey was conducted by using cross sectional-based questionnaire. The knowledge, attitude and practice among Kampung Ladang Sehat population in East Coast Malaysia with reference to correlation between socio demographic factors and MLD's TSB is studied. Conclusion: The TSB among adult population in Kampung Ladang Sehat is postulated towards down surging according to the correlation between variables used in the study.Keywords
Modifiable Lifestyle Disease, Treatment Seeking Behaviour, Quality of Life, Dietary Practice.
- In Silico Analysis of the Betuline from the Fiddler Crab, Uca annulipes and its Antimicrobial as Well as Anti Lung Cancer Activities.
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Authors
Affiliations
1 Universiti Sultan ZainalAbidin, Terengganu, MY
2 Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
3 Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
1 Universiti Sultan ZainalAbidin, Terengganu, MY
2 Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
3 Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1849-1856Abstract
Introduction: <i>In silico</i> analysis of the bioactive compound betuline from the fiddler crab, Uca annulipes and its antimicrobial activities were studied. The fiddler crabs, Uca annulipes were collected from Muttukadu Estuary located on the Kanchipuram District, Tamil Nadu, India, 35 K.M away from Chennai, on the East Coast Road route to Kovalam. Materials and Methods: Fiddler crabs were collected by hand picking method. From the muscle mass of the Crab the bioactive compound was isolated by GC-MS analysis. Molecular docking was performed to identify the protein ligand responsible for the affinity with lung cancer causing tumour cells. Results and Discussion: Hence betuline is the potential lead molecule for the inhibition of lung cancer protein and the most important residues for potential drug target as carbon hydrogen bond, conventional hydrogen bond and Vander Waals interaction. In vitro studies of antimicrobial activities clearly indicated that the different concentrations of betuline bioactive compound have the potential to control the bacteria such as Escherichia coli and Pseudomonas aeruginosa. In vitro studies of anticancer activities also evidently showed the different concentrations of bioactive compound betuline have the potential to control the proliferation of lung cancer cells. Conclusion: Reports are very scanty on this species studied and the reports are very old and hence this present investigation would give latest information on the isolation of bioactive compound for the production of pharmaceutical drugs against the lung cancer. These results will be decisive factor for determining a lead bioactive compound for further drug discovery process for the lung cancer.Keywords
Betuline, Escherichia coli, Lung Cancer, Pseudomonas aeruginosa and Uca annulipes.References
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- In Silico Analysis of the Phenylephrine from the Sand Crab (Emerita asiatica) for its Antimicrobial Activities
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Authors
Affiliations
1 Universiti Sultan Zainal Abidin, Terengganu, MY
2 Research Department of Biotechnology, Hindustan College of Arts and Science, Padur, Chennai – 603103, IN
3 Research Department of Microbiology, Hindustan College of Arts and Science, Padur, Chennai – 603103, IN
1 Universiti Sultan Zainal Abidin, Terengganu, MY
2 Research Department of Biotechnology, Hindustan College of Arts and Science, Padur, Chennai – 603103, IN
3 Research Department of Microbiology, Hindustan College of Arts and Science, Padur, Chennai – 603103, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2145-2152Abstract
Aim: The present investigation gives a detailed report on the analysis of the bioactive compound isolated from the sand crab Emerita asiatica is having better relation with vasoconstriction. Methods: The sand crab Emerita asiatica were collected from Thiruvidandhai beach located on the Kanchipuram District, Tamil Nadu, India, 41 K.M away from Chennai, on the East Coast Road route to Mahabalipuram. Sand crabs were collected by hand picking method. From the muscle mass of the Crab the organic compound was isolated by GC-MS analysis. Molecular docking was also performed to identify the protein ligand responsible for the constriction of blood vessels. Results: The isolated bioactive compound was identified as phenylephrine, an α1 adrenergic receptor which has the potential to lead the molecule for the vasoconstriction. In vitro studies of antibacterial activities clearly indicated that the different concentrations of phenylephrine have the antibacterial activity against the bacteria such as Klebsiella pneumoniae and Staphylococcus aureus. Summary: The present investigation would give latest information on the isolation of bioactive compound for the production of pharmaceutical drugs from marine organisms. These results will be decisive factor for determining a lead bioactive compound for further drug discovery process for the vasoconstriction.Keywords
Emerita asiatica, Klebsiella pneumoniae, Phenylephrine, Staphylococcus aureus, Vasoconstriction.References
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